Selected Publications

For key publications relating to UM171-Expanded Cell Therapy, see www.cordexbio.com/news-publications.

Fares I, et al., Decoding Human Hematopoietic Stem Cell Self-Renewal, Current Stem Cell Reports (2022)

Carvalho VS et al., UM171 Expands immature bone marrow CD34+ Cells From Patients With Telomeropathies, Hematology, Transfusion and Cell Therapy (2022)

Salame N et al., UM171-induced ROS promote antigen cross-presentation of immunogenic peptides by bone marrow-derived mesenchymal stromal cells, Stem Cell Research & Therapy (2022)

Chagraoui J, et al., UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell (2021)

David R. Liu et al., Base editing of haematopoietic stem cells rescues sickle cell disease in mice, Nature (2021)

Capo V, et al., Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis, Haematologica (2020)

Chagraoui J, et al., UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal, PloS ONE (2019)

Porteus M et al., Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting, Molecular Therapy, Nucleic Acids (2018)

Ngom M, et al.,UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells, Molecular Therapy, Methods & Clinical Development (2018)

*Gentner et al., Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy, Stem Cell Reports (2017)

Fares I, et al., Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal, Science (2014)