Publications

2024

Wilkinson A, Take the MYC to expand blood stem cells. Blood

Lire la suite

2024

Chagraoui J, et al., KBTBD4-mediated Reduction of MYC Is Critical For Hematopoietic Stem Cell Expansion Upon UM171 Treatment, Blood

Lire la suite

2022

Fares I, et al., Decoding Human Hematopoietic Stem Cell Self-Renewal, Current Stem Cell Reports (2022)

Lire la suite

2022

Carvalho VS et al., UM171 Expands immature bone marrow CD34+ Cells From Patients With Telomeropathies, Hematology, Transfusion and Cell Therapy

Lire la suite

2022

Salame N et al., UM171-induced ROS promote antigen cross-presentation of immunogenic peptides by bone marrow-derived mesenchymal stromal cells, Stem Cell Research & Therapy

Lire la suite

2021

Chagraoui J, et al., UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell

Lire la suite

2021

David R. Liu et al., Base editing of haematopoietic stem cells rescues sickle cell disease in mice, Nature

Lire la suite

2020

Capo V, et al., Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis, Haematologica

Lire la suite

2019

Chagraoui J, et al., UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal, PloS ONE

Lire la suite

2018

Porteus M et al., Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting, Molecular Therapy, Nucleic Acids

Lire la suite

2018

Ngom M, et al., UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells, Molecular Therapy, Methods & Clinical Development

Lire la suite

2014

Fares I, et al., Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal, Science

Lire la suite