Publications

2024

J.R. Yeo m, et al., Asymmetric Engagement of Dimeric CRL3KBTBD4 by the Molecular Glue UM171 Licenses Degradation of HDAC1/2 Complexes

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2024

Wilkinson A, Take the MYC to expand blood stem cells. Blood

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2024

Chagraoui J, et al., KBTBD4-mediated Reduction of MYC Is Critical For Hematopoietic Stem Cell Expansion Upon UM171 Treatment, Blood

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2022

Fares I, et al., Decoding Human Hematopoietic Stem Cell Self-Renewal, Current Stem Cell Reports (2022)

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2022

Carvalho VS et al., UM171 Expands immature bone marrow CD34+ Cells From Patients With Telomeropathies, Hematology, Transfusion and Cell Therapy

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2022

Salame N et al., UM171-induced ROS promote antigen cross-presentation of immunogenic peptides by bone marrow-derived mesenchymal stromal cells, Stem Cell Research & Therapy

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2021

Chagraoui J, et al., UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex, Cell Stem Cell

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2021

David R. Liu et al., Base editing of haematopoietic stem cells rescues sickle cell disease in mice, Nature

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2020

Capo V, et al., Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis, Haematologica

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2019

Chagraoui J, et al., UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal, PloS ONE

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2018

Porteus M et al., Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting, Molecular Therapy, Nucleic Acids

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2018

Ngom M, et al., UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells, Molecular Therapy, Methods & Clinical Development

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2014

Fares I, et al., Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal, Science

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