ExCellThera’s most advanced technology is based around the UM171 small molecule. UM171 is a first in class activator of a novel protein leading to the degradation of a repressor complex and the activation genes involved in the expression of stem and immune cells.
- Fast & persistent engraftment
- Faster immune reconstitution
- Less gut GvHD
- Reduced TRM
- Anti-leukemic effect
- Epithelium (gut) integrity
ECT-001 offers an increased dose of stem cells for fast engraftment, and provides a high dose of tolerogenic
mast cells, dendritic mature cells and progenitors.
The UM171 molecule permits for the creation of a new
graft, made up of approximately 50% immune cells, contributing to various positive clinical outcomes, such as a reduction of gut Graft versus Host Disease (GvHD).